A Phase 3, Placebo-controlled, Randomized, Observer-blinded Study to Evaluate the Efficacy, Safety, and Tolerability of a Clostridium Difficile Vaccine In Adults 50 Years of Age and Older
A pilot study for Allergan's intravenous antibiotic, Dalvance® (dalbavancin), administered every 14 days for the treatment of Septic Arthritis (2 infusions) and / or Osteomyelitis (3 infusions)
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B3451002 - A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate The Safety and Efficacy of Staphylococcus Aureus 4-Antigen Vaccine (SA4Ag) in Adults Undergoing Elective Posterior Instrumented Lumbar Spinal Fusion Procedures.
A Study to evaluate a Staphylococcus aureus vaccine in patients undergoing elective posterior instrumented lumbar spinal fusion procedures.
Background: Reports of methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus (S. aureus) infections in the United States (U.S.) have become commonplace and are well-known to patients, providers, and healthcare administrators. Many researchers have described this major health problem as one of epidemic proportion because of the scope and magnitude of these infections in the U.S. The incidence of MRSA and S. aureus infections has been a burden on the United States’ healthcare system. Although recent MRSA infection rates have seen a slight decline, S. aureus rates have been stable. Prior to the recent slight MRSA decline, hospitalizations for MRSA infections increased 119% from 1999 to 2005. An astounding 16% of all infections in the US are from S. aureus, and roughly 18% are related to surgical site infections. Despite the best known infection control mechanisms, MRSA and S. aureus will continue to be a high focal point for the healthcare community.
The evolution of vaccinations has proven to be an essential part of population health that positively impacts health outcomes and reduces healthcare related expenses. CARE-ID is one of 55 centers in the world evaluating a S. aureus vaccine in individuals undergoing elective posterior instrumented lumbar spinal fusion procedures. The potential use of a preventative S. aureus vaccine in patients undergoing elective surgery would be a major accomplishment in medicine.
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Closed to Enrollment
ViiV 209035 - This is a “roll-over” study including only current patients from another trial: A Phase IIb, Multicenter, Open-label, Rollover Study Evaluating the Efficacy, Safety and Tolerability of Long-acting Cabotegravir Plus Long-acting Rilpivirine Administered Every Two Months in HIV-1 infected Adults who are Virologically Suppressed and Participated in Study LAI116482
207966 (ATLAS 2) - A study evaluating the efficacy, safety, and tolerability of Long-acting Cabotegravir Plus Long-acting Rilpivirine administered every 4 or 8 weeks in Virologically Suppressed HIV-1-infected adults.
A Phase 3, Randomized, Double-Blinded Study of the Safety and Efficacy of a Fixed Dose Combination of GS-9883/Emtricitabine/Tenofovir Alafenamide Versus Dolutegravir + Emtricitabine/Tenofovir Alafenamide in HIV-1 Infected, Antiretroviral Treatment-Naïve Adults Read More